Phosphorylation of Kinesin inVivo Correlates with Organelle Association and Neurite Outgrowth
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چکیده
منابع مشابه
the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Automated screening of neurite outgrowth.
Outgrowth of neurites in culture is used for assessing neurotrophic activity. Neurite measurements have been performed very slowly using manual methods or more efficiently with interactive image analysis systems. In contrast, medium-throughput and noninteractive image analysis of neurite screens has not been well described. The authors report the performance of an automated image acquisition an...
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Remarkably, forces within a neuron can extend its axon to a target that could be meters away. The two main cytoskeleton components in neurons are microtubules, which are mostly bundled along the axon shaft, and actin filaments, which are highly enriched in a structure at the axon distal tip, the growth cone. Neurite extension has been thought to be driven by a combination of two forces: pushing...
متن کاملNeuronal PAS domain protein 4 ( Npas 4 ) regulates neurite outgrowth and phosphorylation of synapsin I
Background: Npas4 is involved in memory formation, but its roles in neuronal function remain to be fully elucidated. Results: Npas4 increased Cdk5-dependent phosphorylation of synapsin I that was associated with neurite elongation. Conclusion: Npas4 induced Cdk5-dependent phosphorylation of synapsin I to facilitate neurite outgrowth. Significance: Npas4 plays an important role in the structural...
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Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Ab...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.10.5600